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KMID : 0378019820250020135
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New Medical Journal
1982 Volume.25 No. 2 p.135 ~ p.145
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An Experimental Study on the Effect of Korean-blended Alcohol upon the Liver
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Abstract
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With an expansion of alcohol, consumption, the occurrence of corresponding liver disease has been steadily increased. Some investigators reported that alcohol is a calorie substitute predisposing malnutrition, while others have described alcohol as a direct hepatotoxin. Thus, the pathogenesis of alcoholic liver injury has not been settled yet. Furthermore, the mechanism of alcoholic liver disease is also controversial whether alcoholic liver damage is initiated morphologically by steatosis or by marked necrosis with inflammatory cell reaction.
This study was conducted anatopathologically and biochemically to evaluate the effect of alcohol upon the liver. Three hundred healthy Sprague-Dawley rats weighing about 200 gm were used for this experiment and divided into the following 4 groups:
1. Control group fed basic diet.
2. Low-concentrated alcohol administered group given 25% of alcohol.
3. Mid-concentrated alcohol administered group given 32.5% of alcohol.
4. High-concentrated alcohol administered group given 40% of alcohol.
The basic diet was nutritionally composed of adequate solid diet,and each rat was administered orally 20-25gm of basic diet per day.
Alcohol administered group was given orally 20m1 of alcohol, instead of water, in addition to basic diet. Control group was administered basic diet with 20m1 of water. The results obtained from this study were as follows:
1. Serum enzyme levels (GOT, GPT, alkaline phosphatase) were markedly elevated in alcohol administered groups, but direct bilirubin levels were slightly raised.
2. Various degree of cellular swelling, congestion, and bile pigmentation were observed in the liver of alcohol adminstered groups.
3. Fatty degeneration and thickening of venular wall were noted in mid-and high-concentrated alcohol administered groups at 40 days.
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